This article is reproduced from the blog Plant Breeding by Dr. KK Vinod
Scientists and students of genetics studying linkage and recombination are familiar with Kosambi’s mapping function. Chances are that they never had heard of Kosambi before. The reason - Damodar Dharmanada Kosambi was not a geneticist by training and profession, but a mathematician. He was also a statistician, historian, marxist, linguist, writer – he was everything – a multi-faceted scholar. His famous mapping function was published in 1944, in Annals of Eugenics (Kosambi, 1944). How he got into this work is not known, but Kosambi’s works generally spanned across many disciplines from mathematics to children’s literature. At the time of this publication he was teaching mathematics at Fergusson College, Pune.
Recently, Professor Kosambi’s birth centenary was celebrated, in Pune mainly by the historians and scholars. I as a student of genetics, came to know more about Kosambi after this celebrations. Ignorant of a great scientist, whose name I would have used thousands of time while doing genetic map constructions, I decided to put this tribute.
Kosambi’s mapping function estimates the recombination fraction (c) between two loci as a function of the map distance (m) between the loci, by allowing some interference, as
c = ( e4m -1) / 2( e4m +1)
The estimate of the map distance between two loci can be obtained from
m = ln [ (1+2c)/(1-2c) ] /4
Kosambi’s function go intermediate between actual recombination fraction taken as map distance (no interference) and Haldane’s map function (Haldane, 1919), closely predicting recombination fractions especially when the loci are linked.
Damodar Dharmanand Kosambi (D.D. Kosambi) was born at Goa on 31 July 1907 to Acharya Dharmananda Damodar Kosambi and Balabai. After his early schooling, young Kosambi moved to Cambridge, MA (USA) and studied grammer and Latin. After successful schooling at Cmbridge, he joined Harward University in 1924 studying mathematics. He discontinued his studies for a brief period and returned to India, again to join back in 1926, where he was awarded with Bachelor of Arts degree. Returning to India soon after, he joined Banaras Hindu University as a professor, teaching German and mathematics. Here he started his personal research and started publishing his findings. He got married in 1931 with Nalini, and in the same year joined Aligarh Muslim University as the professor of mathematics. He continued his mathematical research more vigorously here, and publishing his papers regularly in European languages.
Two years after he joined Fergusson College in Pune, and continued to teach mathematics. His two daughters Maya and Meera were born here. It was during this period his famous paper on mapping function was published in 1944. Kosambi had done extensive research on many areas of mathematics and published many papers. However, many of his publications went unnoticed by Indian scholars and eventually a great scientist and a historian was getting ignored to a great extend. No students of genetics were told Kosambi was an Indian scientist.
It was probably Homi J Bhabha, who recognised his talents and made him to join Tata Institute of Fundamental Research (TIFR) in 1945. He was professor of mathematics and worked there for next 17 years. During this period, Kosambi published 40 research papers, mostly on mathematics. However, his interest was shifted to history and social sciences in the later years, extensively researching on ancient Sanskrit works, numismatics and ancient history of India. Probably these later works made him to be remembered as a historian rather than a mathematician.
Kosambi authored 9 books including edited ones and 127 articles. But this number is not authentic as there are many childrens’ stories written by him. As a prolific writer, thinker, mathematical genius, linguist and historian Professor Kosambi, as Dale Riepe wrote, ‘deserves to be remembered as one of the highly gifted and versatile scientific workers and indefatigable scholars of modern India for whom a relentless search for the highest human values was the only natural way of life’.
After leaving TIFR, in 1964, Kosambi was appointed as a Scientist Emeritus of the Council of Scientific and Industrial Research (CSIR) and woked in Pune. He got involved in many historical, scientific and archaeological projects, including stories for children. But most of his works that he produced in this period could not be published during his lifetime.
Professor Kosambi died at Pune, at the age of 59, on June 29, 1966. He was posthumously decorated with the Hari Om Ashram Award by the government of India's University Grant Commission in 1980.
A biographical sketch of Prof DD Kosambi written by Chintamani Desdhmukh can be downloaded from here.
References
Haldane, J.B.S (1919) The combination of linkage values, and the calculation of distance between linked factors. Journal of Genetics, 8: 299-309.
Kosambi DD (1944) The estimation of map distance from recombination values, Annals of Eugenics, 12(3): 172-175
***
Scientists and students of genetics studying linkage and recombination are familiar with Kosambi’s mapping function. Chances are that they never had heard of Kosambi before. The reason - Damodar Dharmanada Kosambi was not a geneticist by training and profession, but a mathematician. He was also a statistician, historian, marxist, linguist, writer – he was everything – a multi-faceted scholar. His famous mapping function was published in 1944, in Annals of Eugenics (Kosambi, 1944). How he got into this work is not known, but Kosambi’s works generally spanned across many disciplines from mathematics to children’s literature. At the time of this publication he was teaching mathematics at Fergusson College, Pune.
Recently, Professor Kosambi’s birth centenary was celebrated, in Pune mainly by the historians and scholars. I as a student of genetics, came to know more about Kosambi after this celebrations. Ignorant of a great scientist, whose name I would have used thousands of time while doing genetic map constructions, I decided to put this tribute.
Kosambi’s mapping function estimates the recombination fraction (c) between two loci as a function of the map distance (m) between the loci, by allowing some interference, as
c = ( e4m -1) / 2( e4m +1)
The estimate of the map distance between two loci can be obtained from
m = ln [ (1+2c)/(1-2c) ] /4
Kosambi’s function go intermediate between actual recombination fraction taken as map distance (no interference) and Haldane’s map function (Haldane, 1919), closely predicting recombination fractions especially when the loci are linked.
Damodar Dharmanand Kosambi (D.D. Kosambi) was born at Goa on 31 July 1907 to Acharya Dharmananda Damodar Kosambi and Balabai. After his early schooling, young Kosambi moved to Cambridge, MA (USA) and studied grammer and Latin. After successful schooling at Cmbridge, he joined Harward University in 1924 studying mathematics. He discontinued his studies for a brief period and returned to India, again to join back in 1926, where he was awarded with Bachelor of Arts degree. Returning to India soon after, he joined Banaras Hindu University as a professor, teaching German and mathematics. Here he started his personal research and started publishing his findings. He got married in 1931 with Nalini, and in the same year joined Aligarh Muslim University as the professor of mathematics. He continued his mathematical research more vigorously here, and publishing his papers regularly in European languages.
Two years after he joined Fergusson College in Pune, and continued to teach mathematics. His two daughters Maya and Meera were born here. It was during this period his famous paper on mapping function was published in 1944. Kosambi had done extensive research on many areas of mathematics and published many papers. However, many of his publications went unnoticed by Indian scholars and eventually a great scientist and a historian was getting ignored to a great extend. No students of genetics were told Kosambi was an Indian scientist.
It was probably Homi J Bhabha, who recognised his talents and made him to join Tata Institute of Fundamental Research (TIFR) in 1945. He was professor of mathematics and worked there for next 17 years. During this period, Kosambi published 40 research papers, mostly on mathematics. However, his interest was shifted to history and social sciences in the later years, extensively researching on ancient Sanskrit works, numismatics and ancient history of India. Probably these later works made him to be remembered as a historian rather than a mathematician.
Kosambi authored 9 books including edited ones and 127 articles. But this number is not authentic as there are many childrens’ stories written by him. As a prolific writer, thinker, mathematical genius, linguist and historian Professor Kosambi, as Dale Riepe wrote, ‘deserves to be remembered as one of the highly gifted and versatile scientific workers and indefatigable scholars of modern India for whom a relentless search for the highest human values was the only natural way of life’.
After leaving TIFR, in 1964, Kosambi was appointed as a Scientist Emeritus of the Council of Scientific and Industrial Research (CSIR) and woked in Pune. He got involved in many historical, scientific and archaeological projects, including stories for children. But most of his works that he produced in this period could not be published during his lifetime.
Professor Kosambi died at Pune, at the age of 59, on June 29, 1966. He was posthumously decorated with the Hari Om Ashram Award by the government of India's University Grant Commission in 1980.
A biographical sketch of Prof DD Kosambi written by Chintamani Desdhmukh can be downloaded from here.
References
Haldane, J.B.S (1919) The combination of linkage values, and the calculation of distance between linked factors. Journal of Genetics, 8: 299-309.
Kosambi DD (1944) The estimation of map distance from recombination values, Annals of Eugenics, 12(3): 172-175
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